A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19.(Statistical Data Included): An article from: Human Biology

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Binding: Digital Brand: The Gale Group Format: HTML Label: Wayne State University Press Manufacturer: Wayne State University Press Publication Date: 2001-12-01 Publisher: Wayne State University Press Release Date: 2005-07-28 Studio: Wayne State University Press
Editorial Reviews: This digital document is an article from Human Biology, published by Wayne State University Press on December 1, 2001. The length of the article is 6002 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Abstract Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome l9pl3.2, showed marginal evidence of linkage with a lod ([log.sub.10] of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic [alpha]) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio. Citation Details Title: A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19.(Statistical Data Included) Author: Lisa J. Martin Publication: Human Biology (Refereed) Date: December 1, 2001 Publisher: Wayne State University Press Volume: 73 Issue: 6 Page: 787(14) Article Type: Statistical Data Included Distributed by Thomson Gale